JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis

JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis

Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have revealed major alterations on natural killer (NK) cell homeostasis associated with JAK inhibitions, while information on other innate lymphoi...

Full description

Bibliographic Details
Main Authors: Laura Vian, Mimi T. Le, Nathalia Gazaniga, Jacqueline Kieltyka, Christine Liu, Giuseppe Pietropaolo, Stefania Dell'Orso, Stephen R. Brooks, Yasuko Furumoto, Craig J. Thomas, John J. O'Shea, Giuseppe Sciumè, Massimo Gadina
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
JAK/STAT
cytokines
NK cells
ILC
differentiation
kinase inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02972/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02972/full

Similar Items