CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling

CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling

Abstract Background It has been widely shared that the dysregulation of circular RNA (circRNA) may contribute to the progression of osteoarthritis (OA). OA is characterized by persistent chondrocyte injury. We aimed to clarify the role of circTBX5 in IL-1β-induced chondrocyte injury. Methods The exp...

Full description

Bibliographic Details
Main Authors: Wei Wei, Hongjie Mu, Qiaoyi Cui, Peng Yu, Tong Liu, Tao Wang, Lin Sheng
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
CircTBX5
Osteoarthritis
Chondrocyte
IL-1β
miR-558
MyD88
Online Access:https://doi.org/10.1186/s13018-023-03949-5

Internet

https://doi.org/10.1186/s13018-023-03949-5

Similar Items