Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3

Abstract In breast cancer, nerve presence has been correlated with more invasive disease and worse prognosis, yet the mechanisms by which different types of peripheral nerves drive tumor progression remain poorly understood. In this study, we identified sensory nerves as more abundant in human tripl...

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Bibliographic Details
Main Authors: Thanh T. Le, Samantha L. Payne, Maia N. Buckwald, Lily A. Hayes, Savannah R. Parker, Christopher B. Burge, Madeleine J. Oudin
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00485-z