Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling

Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling

Abstract Galectin 3-binding protein (LGALS3BP, also known as 90K) is a multifunctional glycoprotein involved in immunity and cancer. However, its precise role in colon inflammation and tumorigenesis remains unclear. Here, we showed that Lgals3bp −/− mice were highly susceptible to colitis and colon...

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Bibliographic Details
Main Authors: Sang-Hee Cho, Hyun-Jeong Shim, Mi-Ra Park, Ji-Na Choi, Md Rashedunnabi Akanda, Jun-Eul Hwang, Woo-Kyun Bae, Kyung-Hwa Lee, Eun-Gene Sun, Ik-Joo Chung
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00447-7

Internet

https://doi.org/10.1038/s41420-021-00447-7

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