Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy

Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy

Abstract Background Tumor-draining lymph nodes (TDLNs) are primary sites, where anti-tumor lymphocytes are primed to tumor-specific antigens and play pivotal roles in immune responses against tumors. Although adoptive cell therapy (ACT) using lymphocytes isolated from TDLNs were reported, characteri...

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Bibliographic Details
Main Authors: Kazumi Okamura, Satoshi Nagayama, Tomohiro Tate, Hiu Ting Chan, Kazuma Kiyotani, Yusuke Nakamura
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Adoptive T cell therapy
Tumor-draining lymph nodes
Tumor-infiltrating lymphocytes
Online Access:https://doi.org/10.1186/s12967-022-03444-1

Internet

https://doi.org/10.1186/s12967-022-03444-1

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