Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis

Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease with poor prognosis. The intricacies surrounding its pathophysiology could partly account for the lack of effective treatment for ALS. Sestrin2 has been reported to improve metabolic, cardiovascular and neurodegenerative dise...

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Bibliographic Details
Main Authors: Tian Jin, Yong Zhang, Benson O.A. Botchway, Min Huang, Qicheng Lu, Xuehong Liu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sestrin2
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)
Silent information regulator 1 (SIRT1)
Amyotrophic lateral sclerosis
Neurodegenerative diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003037

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http://www.sciencedirect.com/science/article/pii/S0753332223003037

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