Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Abstract Background Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly mapped for individual mutations in spike, their influ...

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Bibliographic Details
Main Authors: Simon Schröder, Anja Richter, Talitha Veith, Jackson Emanuel, Luca Gudermann, Kirstin Friedmann, Lara M. Jeworowski, Barbara Mühlemann, Terry C. Jones, Marcel A. Müller, Victor M. Corman, Christian Drosten
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Virology Journal
Subjects:
COVID-19
SARS-CoV-2
Reverse genetics
Virus fitness
Antibody neutralization escape
Spike protein evolution
Online Access:https://doi.org/10.1186/s12985-023-02154-4

Internet

https://doi.org/10.1186/s12985-023-02154-4

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