Enhanced Delivery of Therapeutic siRNA into Glioblastoma Cells Using Dendrimer-Entrapped Gold Nanoparticles Conjugated with β-Cyclodextrin

Enhanced Delivery of Therapeutic siRNA into Glioblastoma Cells Using Dendrimer-Entrapped Gold Nanoparticles Conjugated with β-Cyclodextrin

We describe a safe and highly effective non-viral vector system based on β-cyclodextrin (β-CD)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for improved delivery small interfering RNA (siRNA) to glioblastoma cells. In our approach, we utilized amine-terminated generation 5 poly(amidoam...

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Bibliographic Details
Main Authors: Jieru Qiu, Lingdan Kong, Xueyan Cao, Aijun Li, Ping Wei, Lu Wang, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Shi
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Nanomaterials
Subjects:
PAMAM dendrimers
β-CD
gold nanoparticles
gene silencing
siRNA
Online Access:http://www.mdpi.com/2079-4991/8/3/131

Internet

http://www.mdpi.com/2079-4991/8/3/131

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