Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) is a rare pediatric inflammatory disorder characterized by immune cell hyperactivation, cytokine storm, and the production of autoantibodies. The mechanisms underlying such immune dysregulation still need to be unraveled. In this issue of the JCI...
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-01-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI166016 |
| _version_ | 1797634549808627712 |
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| author | Magali Noval Rivas Moshe Arditi |
| author_facet | Magali Noval Rivas Moshe Arditi |
| author_sort | Magali Noval Rivas |
| collection | DOAJ |
| description | Multisystem inflammatory syndrome in children (MIS-C) is a rare pediatric inflammatory disorder characterized by immune cell hyperactivation, cytokine storm, and the production of autoantibodies. The mechanisms underlying such immune dysregulation still need to be unraveled. In this issue of the JCI, Benamar et al. demonstrated the critical role of the Notch receptor 1/CD22 (Notch1/CD22) axis in Tregs, which, when activated, impairs Treg functions and promotes inflammation. They showed that the Notch1/CD22 axis contributed to dysregulated immune responses in MIS-C. These findings may have implications for MIS-C and many other inflammatory diseases. |
| first_indexed | 2024-03-11T12:09:18Z |
| format | Article |
| id | doaj.art-faadb87fe2184006ac0224c06e160d36 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:09:18Z |
| publishDate | 2023-01-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-faadb87fe2184006ac0224c06e160d362023-11-07T16:19:42ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-01-011331Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in childrenMagali Noval RivasMoshe ArditiMultisystem inflammatory syndrome in children (MIS-C) is a rare pediatric inflammatory disorder characterized by immune cell hyperactivation, cytokine storm, and the production of autoantibodies. The mechanisms underlying such immune dysregulation still need to be unraveled. In this issue of the JCI, Benamar et al. demonstrated the critical role of the Notch receptor 1/CD22 (Notch1/CD22) axis in Tregs, which, when activated, impairs Treg functions and promotes inflammation. They showed that the Notch1/CD22 axis contributed to dysregulated immune responses in MIS-C. These findings may have implications for MIS-C and many other inflammatory diseases.https://doi.org/10.1172/JCI166016 |
| spellingShingle | Magali Noval Rivas Moshe Arditi Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children The Journal of Clinical Investigation |
| title | Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children |
| title_full | Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children |
| title_fullStr | Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children |
| title_full_unstemmed | Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children |
| title_short | Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children |
| title_sort | notch1 signaling impairs regulatory t cells during multisystem inflammatory syndrome in children |
| url | https://doi.org/10.1172/JCI166016 |
| work_keys_str_mv | AT magalinovalrivas notch1signalingimpairsregulatorytcellsduringmultisysteminflammatorysyndromeinchildren AT moshearditi notch1signalingimpairsregulatorytcellsduringmultisysteminflammatorysyndromeinchildren |