TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins

TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins

Mitochondrial diseases are a group of heterogeneous disorders caused by dysfunctional mitochondria. Interestingly, a large proportion of mitochondrial diseases are caused by defects in genes associated with tRNA metabolism. We recently discovered that partial loss-of-function mutations in tRNA Nucle...

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Bibliographic Details
Main Authors: Thet Fatica, Turaya Naas, Urszula Liwak, Hannah Slaa, Maryam Souaid, Brianna Frangione, Ribal Kattini, Antoine Gaudreau-Lapierre, Laura Trinkle-Mulcahy, Pranesh Chakraborty, Martin Holcik
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Genes
Subjects:
SIFD
TRNT1
tiRNA
CCA adding
oxidative stress
SILAC
Online Access:https://www.mdpi.com/2073-4425/14/5/1043

Internet

https://www.mdpi.com/2073-4425/14/5/1043

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