Agonistic and antagonistic targeting of immune checkpoint molecules differentially regulate osteoclastogenesis

Agonistic and antagonistic targeting of immune checkpoint molecules differentially regulate osteoclastogenesis

IntroductionImmune checkpoint inhibitors are used in the treatment of various cancers and have been extensively researched with regard to inflammatory and autoimmune diseases. However, this revolutionary therapeutic strategy often provokes critical auto-inflammatory adverse events, such as inflammat...

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Bibliographic Details
Main Authors: Victoria C. Brom, Andreas C. Strauss, Alexander Sieberath, Jochen Salber, Christof Burger, Dieter C. Wirtz, Frank A. Schildberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint molecules
osteoclasts
osteolysis
osteoporosis
endoprosthesis loosening
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.988365/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.988365/full

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