Carcinoma-Associated Mesenchymal Stem Cells Promote Chemoresistance in Ovarian Cancer Stem Cells via PDGF Signaling

Carcinoma-Associated Mesenchymal Stem Cells Promote Chemoresistance in Ovarian Cancer Stem Cells via PDGF Signaling

Within the ovarian cancer tumor microenvironment, cancer stem-like cells (CSC) interact with carcinoma associated mesenchymal stem/stromal cells (CA-MSC) through multiple secreted cytokines and growth factors. These paracrine interactions have been revealed to cause enrichment of CSC and their chemo...

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Bibliographic Details
Main Authors: Shreya Raghavan, Catherine S. Snyder, Anni Wang, Karen McLean, Dmitriy Zamarin, Ronald J. Buckanovich, Geeta Mehta
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
ovarian cancer
cancer stem-like cells (CSC)
carcinoma associated mesenchymal stem cells (CA-MSC)
platelet derived growth factor (PDGF)
stemness
chemoresistance
Online Access:https://www.mdpi.com/2072-6694/12/8/2063

Internet

https://www.mdpi.com/2072-6694/12/8/2063

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