Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats

Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats

Intrauterine growth retardation (IUGR) poses a high risk for developing late-onset, non-obese type 2 diabetes (T2DM). The exact mechanism underlying this phenomenon is unknown, although the contribution of the central nervous system is recognized. The main hypothalamic nuclei involved in the homeost...

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Bibliographic Details
Main Authors: Máté Durst, Katalin Könczöl, Klementina Ocskay, Klaudia Sípos, Péter Várnai, Anett Szilvásy-Szabó, Csaba Fekete, Zsuzsanna E. Tóth
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Neuroscience
Subjects:
IP-ITT
IP-GTT
neuronal birth dating
cFos
arcuate nucleus
nesfatin-1
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.828571/full

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