Bioenergetic Profiling of the Differentiating Human MDS Myeloid Lineage with Low and High Bone Marrow Blast Counts

Bioenergetic Profiling of the Differentiating Human MDS Myeloid Lineage with Low and High Bone Marrow Blast Counts

Myelodysplastic syndromes (MDS) encompass a very heterogeneous group of clonal hematopoietic stem cell differentiation disorders with malignant potential and an elusive pathobiology. Given the central role of metabolism in effective differentiation, we performed an untargeted metabolomic analysis of...

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Bibliographic Details
Main Authors: Aikaterini Poulaki, Theodora Katsila, Ioanna E. Stergiou, Stavroula Giannouli, Jose Carlos Gόmez-Tamayo, Evangelia-Theophano Piperaki, Konstantinos Kambas, Aglaia Dimitrakopoulou, George P. Patrinos, Athanasios G. Tzioufas, Michael Voulgarelis
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
myelodysplastic syndrome
metabolomics
acute myeloid leukemia
epigenetics
Warburg effect
redox
Online Access:https://www.mdpi.com/2072-6694/12/12/3520

Internet

https://www.mdpi.com/2072-6694/12/12/3520

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