Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products

Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products

Cellular immunotherapies based on T cell receptor (TCR) transfer are promising approaches for the treatment of cancer and chronic viral infections. The discovery of novel receptors is expanding considerably; however, the clinical development of TCR-T cell therapies still lags. Here we provide a pipe...

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Bibliographic Details
Main Authors: Daniela Nascimento Silva, Michael Chrobok, Giulia Rovesti, Katie Healy, Arnika Kathleen Wagner, Panagiota Maravelia, Francesca Gatto, Massimiliano Mazza, Lucia Mazzotti, Volker Lohmann, Margaret Sällberg Chen, Matti Sällberg, Marcus Buggert, Anna Pasetto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
T cell modification
process development
pipeline
TCR-T cells manufacturing
clinical scale
academia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.896242/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.896242/full

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