The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

Regeneration of skeletal muscle in adults is mediated by satellite stem cells. Accumulation of misfolded proteins triggers endoplasmic reticulum stress that leads to unfolded protein response (UPR). The UPR is relayed to the cell through the activation of PERK, IRE1/XBP1, and ATF6. Here, we demonstr...

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Bibliographic Details
Main Authors: Guangyan Xiong, Sajedah M Hindi, Aman K Mann, Yann S Gallot, Kyle R Bohnert, Douglas R Cavener, Scott R Whittemore, Ashok Kumar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
satellite cells
skeletal muscle regeneration
ER Stress
PERK
IRE1/XBP1
survival
Online Access:https://elifesciences.org/articles/22871

Internet

https://elifesciences.org/articles/22871

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