Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action

Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action

We have earlier reported anticancer activity in Withaferin A (Wi-A), a withanolide derived from Ashwagandha (<i>Withania somnifera</i>) and caffeic acid phenethyl ester (CAPE), an active compound from New Zealand honeybee propolis. Whereas Wi-A was cytotoxic to both cancer and normal cel...

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Bibliographic Details
Main Authors: Anissa Nofita Sari, Priyanshu Bhargava, Jaspreet Kaur Dhanjal, Jayarani F. Putri, Navaneethan Radhakrishnan, Seyad Shefrin, Yoshiyuki Ishida, Keiji Terao, Durai Sundar, Sunil C. Kaul, Renu Wadhwa
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
Ashwagandha
Withaferin A
Honeybee propolis
CAPE
Cancer
Mortalin
Online Access:https://www.mdpi.com/2072-6694/12/5/1160

Internet

https://www.mdpi.com/2072-6694/12/5/1160

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