Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

Abstract Background Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability and being partly determined by a genetic component, the genetic underpinnings expl...

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Bibliographic Details
Main Authors: Silvia Alemany, María Soler-Artigas, Judit Cabana-Domínguez, Dana Fakhreddine, Natalia Llonga, Laura Vilar-Ribó, Amanda Rodríguez-Urrutia, Judit Palacio, Ana María González-Castro, Beatriz Lobo, Carmen Alonso-Cotoner, Magnus Simrén, Javier Santos, Josep Antoni Ramos-Quiroga, Marta Ribasés
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Translational Medicine
Subjects:
Irritable bowel syndrome (IBS)
Neuroticism
Depression
Anxiety
Multi-trait genome-wide association study (MTAG)
Online Access:https://doi.org/10.1186/s12967-023-04107-5

Internet

https://doi.org/10.1186/s12967-023-04107-5

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