Engineering CAR T cells for enhanced efficacy and safety

Despite its success in treating hematologic malignancies, chimeric antigen receptor (CAR) T cell therapy faces two major challenges which hinder its broader applications: the limited effectiveness against solid tumors and the nonspecific toxicities. To address these concerns, researchers have used s...

Full description

Bibliographic Details
Main Authors: Yiqian Wu, Ziliang Huang, Reed Harrison, Longwei Liu, Linshan Zhu, Yinglin Situ, Yingxiao Wang
Format: Article
Language:English
Published: AIP Publishing LLC 2022-03-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0073746