The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice

The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice

The angiotensin II (type 1) (AT1) receptor blocker telmisartan (TEL) is beneficial for the treatment of individuals suffering from metabolic syndrome. As we have shown that TEL has an impact on gut microbiota, we investigated here whether TEL influences gut barrier function. C57BL/6N mice were fed w...

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Bibliographic Details
Main Authors: Laura Nickel, Annika Sünderhauf, Elias Rawish, Ines Stölting, Stefanie Derer, Christoph Thorns, Urte Matschl, Alaa Othman, Christian Sina, Walter Raasch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
AT1 receptor antagonist
mucus thickness
obesity
necroptosis
MUC2 gene expression
telmisartan
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.815353/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.815353/full

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