Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons

Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons

Abstract Cell membranes consist of heterogeneous lipid nanodomains that influence key cellular processes. Using FRET-based fluorescent assays and fluorescence lifetime imaging microscopy (FLIM), we find that the dimension of cholesterol-enriched ordered membrane domains (OMD) varies considerably, de...

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Bibliographic Details
Main Authors: Lucas J. Handlin, Natalie L. Macchi, Nicolas L. A. Dumaire, Lyuba Salih, Erin N. Lessie, Kyle S. McCommis, Aubin Moutal, Gucan Dai
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54053-z

Internet

https://doi.org/10.1038/s41467-024-54053-z

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