Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

Electroporation (EP) of mammalian tissue is a technique that has been used successfully in the clinic for the delivery of genetic-based vaccines in the form of DNA plasmids. There is great interest in platforms which efficiently deliver RNA molecules such as messenger RNA and small interfering RNA (...

Full description

Bibliographic Details
Main Authors: Kate E Broderick, Amy Chan, Feng Lin, Xuefei Shen, Gleb Kichaev, Amir S Khan, Justin Aubin, Tracy S Zimmermann, Niranjan Y. Sardesai
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
dermal
DNA vaccine
electroporation
electrotransfer
gene transfer
plasmid DNA
small interfering RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300695

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116300695

Similar Items