Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression

Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis ha...

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Bibliographic Details
Main Authors: James Drury, Piotr G. Rychahou, Courtney O. Kelson, Mariah E. Geisen, Yuanyuan Wu, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Yekaterina Y. Zaytseva
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
colorectal cancer
metastasis
fatty-acid metabolism
CD36
MMP28
E-cadherin
Online Access:https://www.mdpi.com/2072-6694/14/1/252

Internet

https://www.mdpi.com/2072-6694/14/1/252

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