PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats

PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats

Epidemiological and animal studies indicate that pre-existing diabetes increases the risk of Parkinson's disease (PD). However, the mechanisms underlying this association remain unclear. In the present study, we found that high glucose (HG) levels in the cerebrospinal fluid (CSF) of diabetic ra...

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Bibliographic Details
Main Authors: Ya Zhao, Yanwei Wang, Yuying Wu, Cimin Tao, Rui Xu, Yong Chen, Linghui Qian, Tengfei Xu, Xiaoyuan Lian
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Type 1 diabetes mellitus
Hyperglycolysis
Mitochondrial fusion
PKM2
Neuronal vulnerability
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177922001198

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http://www.sciencedirect.com/science/article/pii/S2095177922001198

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