Long-term menopause exacerbates vaginal wall support injury in ovariectomized rats by regulating amino acid synthesis and glycerophospholipid metabolism

Long-term menopause exacerbates vaginal wall support injury in ovariectomized rats by regulating amino acid synthesis and glycerophospholipid metabolism

PurposeMenopause is a risk factor for pelvic organ prolapse (POP) and is frequently associated with diminished vaginal wall support. To uncover relevant molecular mechanisms and provide potential therapeutic targets, we evaluated changes in the transcriptome and metabolome of the vaginal wall in ova...

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Bibliographic Details
Main Authors: Xia Yu, Li He, Wenyi Lin, Xuemei Zheng, Ling Zhang, Bo Yu, Yanjun Wang, Zhenglin Yang, Yonghong Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
pelvic organ prolapse
menopause
vaginal wall
mechanical properties
transcriptomic
metabolomic
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1119599/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1119599/full

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