Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency.

Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency.

Adjustment of daily hydrocortisone dose on clinical criteria lacks sensitivity for fine tuning. Long term hydrocortisone (HC) over-replacement may lead to increased morbidity and mortality in patients with adrenal insufficiency (AI). Biochemical criteria may help detecting over- or under-replacement...

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Bibliographic Details
Main Authors: Elise Rousseau, Michael Joubert, Géraldine Trzepla, Jean Jacques Parienti, Thomas Freret, Marie Christine Vanthygem, Rachel Desailloud, Hervé Lefebvre, Antoine Coquerel, Yves Reznik, PHAD Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4552782?pdf=render

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http://europepmc.org/articles/PMC4552782?pdf=render

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