Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

<p>Abstract</p> <p>Background</p> <p>X11-family proteins, including X11, X11-like (X11L) and X11-like 2 (X11L2), bind to the cytoplasmic domain of amyloid β-protein precursor (APP) and regulate APP metabolism. Both X11 and X11L are expressed specifically in brain, while...

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Main Authors: Kondo Maho, Shiono Maki, Itoh Genzo, Takei Norio, Matsushima Takahide, Maeda Masahiro, Taru Hidenori, Hata Saori, Yamamoto Tohru, Saito Yuhki, Suzuki Toshiharu
Format: Article
Language:English
Published: BMC 2010-09-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/5/1/35

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http://www.molecularneurodegeneration.com/content/5/1/35

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