In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions

In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions

Abstract Background Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics. FAP-targeting radiotracers have demonstrated to be superior to [18F]FDG PET...

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Bibliographic Details
Main Authors: Circe D. van der Heide, Hanyue Ma, Mark W.H. Hoorens, Joana D. Campeiro, Debra C. Stuurman, Corrina M.A. de Ridder, Yann Seimbille, Simone U. Dalm
Format: Article
Language:English
Published: SpringerOpen 2024-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Cancer-associated fibroblast (CAF)
Fibroblast activation protein (FAP)
Radionuclide theranostics
Small molecule inhibitor
(4-quinolinoyl)-glycyl-2-cyanopyrrolidine (QCP)
Online Access:https://doi.org/10.1186/s41181-024-00283-x

Internet

https://doi.org/10.1186/s41181-024-00283-x

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