Synthesis and Preclinical Evaluation of Two Novel <sup>68</sup>Ga-Labeled Bispecific PSMA/FAP-Targeted Tracers with 2-Nal-Containing PSMA-Targeted Pharmacophore and Pyridine-Based FAP-Targeted Pharmacophore

Synthesis and Preclinical Evaluation of Two Novel <sup>68</sup>Ga-Labeled Bispecific PSMA/FAP-Targeted Tracers with 2-Nal-Containing PSMA-Targeted Pharmacophore and Pyridine-Based FAP-Targeted Pharmacophore

Some bispecific radiotracers have been developed to overcome the limitations of monospecific tracers and improve detection sensitivity for heterogeneous tumor lesions. Here, we aim to synthesize two bispecific tracers targeting prostate-specific membrane antigen (PSMA) and fibroblast activation prot...

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Bibliographic Details
Main Authors: Arsyangela Verena, Helen Merkens, Chao-Cheng Chen, Devon E. Chapple, Lei Wang, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
bispecific radiotracers
PSMA
FAP
PET/CT
gallium-68
prostate cancer
Online Access:https://www.mdpi.com/1420-3049/29/4/800

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https://www.mdpi.com/1420-3049/29/4/800

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