The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design

The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design

The insulin-degrading enzyme (IDE) is a Zn<sup>2+</sup> peptidase originally discovered as the main enzyme involved in the degradation of insulin and other amyloidogenic peptides, such as the β-amyloid (Aβ) peptide. Therefore, a role for the IDE in the cure of diabetes and Alzheimer’s di...

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Bibliographic Details
Main Authors: Grazia Raffaella Tundo, Giuseppe Grasso, Marco Persico, Oleh Tkachuk, Francesco Bellia, Alessio Bocedi, Stefano Marini, Mariacristina Parravano, Grazia Graziani, Caterina Fattorusso, Diego Sbardella
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomolecules
Subjects:
insulin-degrading enzyme
Alzheimer’s disease
diabetes
proteasome
insulin
allostery
Online Access:https://www.mdpi.com/2218-273X/13/10/1492

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https://www.mdpi.com/2218-273X/13/10/1492

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