Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.

Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.

To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validat...

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Bibliographic Details
Main Authors: Sing Teang Kong, Shih-Hui Lim, Wee Beng Lee, Pasikanthi Kishore Kumar, Hwee Yi Stella Wang, Yan Lam Shannon Ng, Pei Shieen Wong, Paul C Ho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4177879?pdf=render

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http://europepmc.org/articles/PMC4177879?pdf=render

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