Promotor Hypomethylation Mediated Upregulation of miR-23b-3p Targets PTEN to Promote Bronchial Epithelial-Mesenchymal Transition in Chronic Asthma

Promotor Hypomethylation Mediated Upregulation of miR-23b-3p Targets PTEN to Promote Bronchial Epithelial-Mesenchymal Transition in Chronic Asthma

Chronic asthma is characterized by airway inflammation and irreversible airway remodeling. Epithelial-mesenchymal transition (EMT) is a typical pathological change of airway remodeling. Our previous research demonstrated miR-23b inhibited airway smooth muscle proliferation while the function of miR-...

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Bibliographic Details
Main Authors: Yimin Guo, Xiaoqing Yuan, Luna Hong, Qiujie Wang, Shanying Liu, Zhaolin Li, Linjie Huang, Shanping Jiang, Jianting Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
chronic asthma
miR-23b-3p
DNA hypomethylation
EMT
PTEN
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.771216/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.771216/full

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