4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters

4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters

Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol. Our aim was to elucidate the roles of PXR and oxysterols in the regulation of cholesterol transporte...

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Bibliographic Details
Main Authors: Tuire Salonurmi, Heba Nabil, Justiina Ronkainen, Tuulia Hyötyläinen, Heidi Hautajärvi, Markku J. Savolainen, Ari Tolonen, Matej Orešič, Päivi Känsäkoski, Jaana Rysä, Jukka Hakkola, Janne Hukkanen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
4β-hydroxycholesterol
ATP binding cassette transporter A1
ATP binding cassette transporter G1
inducible degrader of the LDL receptor
lectin-like oxidized LDL receptor-1
liver X receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00361/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00361/full

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