Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives
Piperine (1) was obtained from the seeds of Piper nigrum L. It could act as a pan-histone deacetylase (HDAC) inhibitor. This lead compound was structurally modified to six derivatives that exhibited improved HDAC inhibitory activity. Based on the preliminary results, amide derivatives (1e and 1f)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Prince of Songkla University
2022-12-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://sjst.psu.ac.th/journal/44-6/12.pdf |