Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives

Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives

Piperine (1) was obtained from the seeds of Piper nigrum L. It could act as a pan-histone deacetylase (HDAC) inhibitor. This lead compound was structurally modified to six derivatives that exhibited improved HDAC inhibitory activity. Based on the preliminary results, amide derivatives (1e and 1f)...

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Bibliographic Details
Main Authors: La-or Somsakeesit, Anupong Joompang, Santi Phosr, Pattaravadee Srikoon, Pakit Kumboonma, Thanaset Senawong, Chanokbhorn Phaosiri
Format: Article
Language:English
Published: Prince of Songkla University 2022-12-01
Series:Songklanakarin Journal of Science and Technology (SJST)
Subjects:
piper nigrum l.
piperine
piperine derivative
hdac
hela cell
Online Access:https://sjst.psu.ac.th/journal/44-6/12.pdf

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