DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues

DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues

Abstract Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of disease-associated mutations in the Human Gene Mutation Database (HGMD). Despite numerous s...

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Bibliographic Details
Main Authors: Kian Hong Kock, Patrick K. Kimes, Stephen S. Gisselbrecht, Sachi Inukai, Sabrina K. Phanor, James T. Anderson, Gayatri Ramakrishnan, Colin H. Lipper, Dongyuan Song, Jesse V. Kurland, Julia M. Rogers, Raehoon Jeong, Stephen C. Blacklow, Rafael A. Irizarry, Martha L. Bulyk
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47396-0

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https://doi.org/10.1038/s41467-024-47396-0

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