Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs

Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs

Many peptide-activated rhodopsin-like GPCRs share a β-hairpin folding motif in the extracellular loop 2 (ECL2), which interacts with the peptide ligand while at the same time being connected to transmembrane helix 3 (TM3) via a highly conserved disulfide bond. Currently, it remains unknown whether t...

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Bibliographic Details
Main Authors: Marcel M. Wygas, Jeannette M. Laugwitz, Peter Schmidt, Matthias Elgeti, Anette Kaiser
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
peptide G-protein-coupled receptor (GPCR)
extracellular loop
conserved disulfide
electron paramagnetic resonance (EPR)
functional selectivity
arrestin
Online Access:https://www.mdpi.com/1422-0067/24/15/12197

Internet

https://www.mdpi.com/1422-0067/24/15/12197

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