Neoantigen cancer vaccine augments anti-CTLA-4 efficacy

Abstract Immune checkpoint inhibitors (ICI) based on anti-CTLA-4 (αCTLA-4) and anti-PD1 (αPD1) are being tested in combination with different therapeutic approaches including other immunotherapies such as neoantigen cancer vaccines (NCV). Here we explored, in two cancer murine models, different ther...

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Bibliographic Details
Main Authors: Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Antonella Conforti, Gennaro Ciliberto, Luigi Aurisicchio, Fabio Palombo
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00433-9