Serum concentrations of substance P in cholestasis

Substance P (SP) is an excitatory neuropeptide that acts via the neurokinin-I receptor (NK-1) in the nervous system. Pruritus, a complication of cholestasis, is a nociceptive stimulus; thus, we hypothesized that cholestasis would be associated with increased neurotransmission via SP as evidenced, in...

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Bibliographic Details
Main Authors: Mayur Trivedi, Nora V. Bergasa, M.D.
Format: Article
Language:English
Published: Elsevier 2010-04-01
Series:Annals of Hepatology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119316588