Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties.

Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties.

Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation. Earlier, we identified somatic mutations in POLG1 and the contribution of these mutations in human cancer. However, a role for germline vari...

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Bibliographic Details
Main Authors: Bhupendra Singh, Kjerstin M Owens, Prachi Bajpai, Mohamed Mokhtar Desouki, Vinodh Srinivasasainagendra, Hemant K Tiwari, Keshav K Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4607296?pdf=render

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http://europepmc.org/articles/PMC4607296?pdf=render

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