Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.

Bibliográfalaš dieđut
Váldodahkkit: Naoki Yoneda, Yuki Fujii, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Nature Portfolio 2017-11-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/s41467-017-01099-x