Dual separable feedback systems govern firing rate homeostasis

Firing rate homeostasis (FRH) stabilizes neural activity. A pervasive and intuitive theory argues that a single variable, calcium, is detected and stabilized through regulatory feedback. A prediction is that ion channel gene mutations with equivalent effects on neuronal excitability should invoke th...

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Bibliographic Details
Main Authors: Yelena Kulik, Ryan Jones, Armen J Moughamian, Jenna Whippen, Graeme W Davis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/45717