Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Plays a Protective Effect Against Noise-Induced Hearing Loss

Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Plays a Protective Effect Against Noise-Induced Hearing Loss

Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal polypeptide (VIP)-the secretin-glucagon family of neuropeptides. They act through two classes of receptors: PACAP type 1 (PAC1) and type 2 (VPAC1 and VPAC2). Among their pleiotropic effects throughout...

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Bibliographic Details
Main Authors: Jérôme Ruel, Matthieu J. Guitton, Paul Gratias, Marc Lenoir, Sanbing Shen, Jean-Luc Puel, Philippe Brabet, Jing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
acoustic trauma
PACAP (pituitary adenylate cyclase-activating polypeptide)
PAC1 receptor
neuroprotection
noise-induced hearing loss (NIHL)
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.658990/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.658990/full

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