Clonal evolution of the 3D chromatin landscape in patients with relapsed pediatric B-cell acute lymphoblastic leukemia

Clonal evolution of the 3D chromatin landscape in patients with relapsed pediatric B-cell acute lymphoblastic leukemia

Abstract Relapsed pediatric B-cell acute lymphoblastic leukemia (B-ALL) remains one of the leading causes of cancer mortality in children. We performed Hi-C, ATAC-seq, and RNA-seq on 12 matched diagnosis/relapse pediatric leukemia specimens to uncover dynamic structural variants (SVs) and 3D chromat...

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Main Authors: Sonali Narang, Yohana Ghebrechristos, Nikki A. Evensen, Nina Murrell, Sylwia Jasinski, Talia H. Ostrow, David T. Teachey, Elizabeth A. Raetz, Timothee Lionnet, Matthew Witkowski, Iannis Aifantis, Aristotelis Tsirigos, William L. Carroll
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51492-6

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https://doi.org/10.1038/s41467-024-51492-6

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