Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine

Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine

The presence of stereogenic elements is a common feature in pharmaceutical compounds, and affording optically pure stereoisomers is a frequent issue in drug design. In this context, the study of the chiral molecular recognition mechanism fundamentally supports the understanding and optimization of c...

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Bibliographic Details
Main Authors: Roberta Franzini, Marco Pierini, Andrea Mazzanti, Antonia Iazzetti, Alessia Ciogli, Claudio Villani
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
chiral molecular recognition
chirality
enantioselective HPLC
molecular docking
VT-NMR
conformational chirality
Online Access:https://www.mdpi.com/1422-0067/22/1/144

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https://www.mdpi.com/1422-0067/22/1/144

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