Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Abstract Background Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system. In...

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Bibliographic Details
Main Authors: Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo, Guokun Wang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cellular & Molecular Biology Letters
Subjects:
Diabetic cardiomyopathy
Cardiomyocytes
Oxidative stress
MicroRNA
MAP kinase interacting serine/threonine kinase 2
Online Access:https://doi.org/10.1186/s11658-022-00379-9

Internet

https://doi.org/10.1186/s11658-022-00379-9

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