In Vitro Activity of Auranofin in Combination With Aztreonam-Avibactam Against Metallo-β-lactamase (MBL)-Producing Enterobacterales

In Vitro Activity of Auranofin in Combination With Aztreonam-Avibactam Against Metallo-β-lactamase (MBL)-Producing Enterobacterales

ObjectivesTo assess the efficacy of aztreonam-avibactam-auranofin (ATM-AVI-AUR) against a collection of 88 carbapenemase-producing Enterobacterales (CPE) clinical isolates and 6 in vitro selected ATM-AVI-resistant CPE with CMY-16 Tyr150Ser and Asn346His mutants or transformants.MethodsMICs of imipen...

Full description

Bibliographic Details
Main Authors: Wen Wang, Shifeng Huang, Chunhong Zou, Yanhui Ding, Huijuan Wang, Shuli Pu, Yunfeng Liao, Hong Du, Deqiang Wang, Liang Chen, Siqiang Niu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
carbapenem-resistant Enterobacterales
carbapenemase-producing Enterobacterales
metallo-β-lactamases
serine-β-lactamases
ceftazidime-avibactam
aztreonam-avibactam
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.755763/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.755763/full

Similar Items