Diversity and distribution of sulfur metabolic genes in the human gut microbiome and their association with colorectal cancer

Abstract Background Recent evidence implicates microbial sulfidogenesis as a potential trigger of colorectal cancer (CRC), highlighting the need for comprehensive knowledge of sulfur metabolism within the human gut. Microbial sulfidogenesis produces genotoxic hydrogen sulfide (H2S) in the human colo...

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Bibliographic Details
Main Authors: Patricia G. Wolf, Elise S. Cowley, Adam Breister, Sarah Matatov, Luke Lucio, Paige Polak, Jason M. Ridlon, H. Rex Gaskins, Karthik Anantharaman
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Microbiome
Subjects:
Online Access:https://doi.org/10.1186/s40168-022-01242-x