ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Abstract Background Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known as cerebral amyloid angiopathy (CAA), microhemorrhage...

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Bibliographic Details
Main Authors: Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens, Cheryl L. Wellington
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
High-density lipoproteins
Apolipoprotein A-I (apoA-I)
Amyloid beta
Cerebral amyloid angiopathy
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s13195-019-0497-9

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http://link.springer.com/article/10.1186/s13195-019-0497-9

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