Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling
Type 2 diabetes (T2DM) clinically exhibits a higher incidence of hepatocellular carcinoma (HCC), contributing to a lousy prognosis in patients harboring both diseases. Microflora-based therapy draws attention with low side effects. Accumulating evidence shows that Lactobacillus brevis can improve bl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1179014/full |
| _version_ | 1797830002318770176 |
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| author | Shujia Chen Ping Han Qian Zhang Peiyan Liu Jie Liu Lili Zhao Lianyi Guo Jia Li |
| author_facet | Shujia Chen Ping Han Qian Zhang Peiyan Liu Jie Liu Lili Zhao Lianyi Guo Jia Li |
| author_sort | Shujia Chen |
| collection | DOAJ |
| description | Type 2 diabetes (T2DM) clinically exhibits a higher incidence of hepatocellular carcinoma (HCC), contributing to a lousy prognosis in patients harboring both diseases. Microflora-based therapy draws attention with low side effects. Accumulating evidence shows that Lactobacillus brevis can improve blood glucose and body weight of the T2DM mice model and reduce several cancer incidences. However, the therapeutic effect of Lactobacillus brevis in affecting the prognosis of T2DM+HCC remains unknown. In this study, we aim to explore this question via an established T2DM+HCC mice model. We observed a significant alleviation after the probiotic intervention. Lactobacillus brevis improves blood glucose and insulin resistance and ameliorates Mechanically. Combined with a multi-omics approach including 16SrDNA, GC-MS, and RNA-seq, we identified distinct intestinal microflora composition and metabolites after Lactobacillus brevis intervention. Furthermore, we found that Lactobacillus brevis delayed disease progression by regulating MMP9 and NOTCH 1 signaling pathways, potentially through gut microflora and BA interaction. This study indicates that Lactobacillus brevis may improve the prognosis of T2DM + HCC, providing novel therapeutic opportunities via targeting intestinal flora for patients with T2DM+HCC. |
| first_indexed | 2024-04-09T13:29:09Z |
| format | Article |
| id | doaj.art-fb2cab26344c4b87ba1333214feed892 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T13:29:09Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fb2cab26344c4b87ba1333214feed8922023-05-10T05:15:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11790141179014Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signalingShujia Chen0Ping Han1Qian Zhang2Peiyan Liu3Jie Liu4Lili Zhao5Lianyi Guo6Jia Li7Clinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin, ChinaClinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin, ChinaClinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin, ChinaClinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Hepatology, Tianjin Second People’s Hospital, Tianjin, ChinaDepartment of Hepatology, Tianjin Second People’s Hospital, Tianjin, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Hepatology, Tianjin Second People’s Hospital, Tianjin, ChinaType 2 diabetes (T2DM) clinically exhibits a higher incidence of hepatocellular carcinoma (HCC), contributing to a lousy prognosis in patients harboring both diseases. Microflora-based therapy draws attention with low side effects. Accumulating evidence shows that Lactobacillus brevis can improve blood glucose and body weight of the T2DM mice model and reduce several cancer incidences. However, the therapeutic effect of Lactobacillus brevis in affecting the prognosis of T2DM+HCC remains unknown. In this study, we aim to explore this question via an established T2DM+HCC mice model. We observed a significant alleviation after the probiotic intervention. Lactobacillus brevis improves blood glucose and insulin resistance and ameliorates Mechanically. Combined with a multi-omics approach including 16SrDNA, GC-MS, and RNA-seq, we identified distinct intestinal microflora composition and metabolites after Lactobacillus brevis intervention. Furthermore, we found that Lactobacillus brevis delayed disease progression by regulating MMP9 and NOTCH 1 signaling pathways, potentially through gut microflora and BA interaction. This study indicates that Lactobacillus brevis may improve the prognosis of T2DM + HCC, providing novel therapeutic opportunities via targeting intestinal flora for patients with T2DM+HCC.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1179014/fulltype 2 diabeteshepatocellular carcinomaLactobacillus brevisgut microflorabile acidsNOTCH 1 signaling |
| spellingShingle | Shujia Chen Ping Han Qian Zhang Peiyan Liu Jie Liu Lili Zhao Lianyi Guo Jia Li Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling Frontiers in Immunology type 2 diabetes hepatocellular carcinoma Lactobacillus brevis gut microflora bile acids NOTCH 1 signaling |
| title | Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling |
| title_full | Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling |
| title_fullStr | Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling |
| title_full_unstemmed | Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling |
| title_short | Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling |
| title_sort | lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora bile acid and notch 1 signaling |
| topic | type 2 diabetes hepatocellular carcinoma Lactobacillus brevis gut microflora bile acids NOTCH 1 signaling |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1179014/full |
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